{"id":394,"date":"2018-11-18T10:54:11","date_gmt":"2018-11-18T02:54:11","guid":{"rendered":"http:\/\/tre.tech.blog\/2018\/11\/18\/%e4%bb%a3%e7%b3%96-%e4%b9%9f%e6%9c%83%e5%bc%95%e8%b5%b7%e8%83%b0%e5%b3%b6%e7%b4%a0%e7%9a%84%e5%8f%8d%e6%87%89%ef%bc%9f%e6%88%96%e8%a8%b1%e6%88%91%e5%80%91%e6%87%89%e5%af%a9%e6%85%8e%e6%80%9d%e8%80%83\/"},"modified":"2018-11-18T10:54:11","modified_gmt":"2018-11-18T02:54:11","slug":"sugar-substitute-insulin-response","status":"publish","type":"post","link":"https:\/\/nutrinote.co\/sugar-substitute-insulin-response\/","title":{"rendered":"\u4eba\u5de5\u751c\u5473\u5291\u4e5f\u6703\u5f15\u8d77\u80f0\u5cf6\u7d20\u7684\u53cd\u61c9\uff1f"},"content":{"rendered":"\n<p>\u4ee3\u7cd6\u5206\u6709\u5929\u7136\u8207\u4eba\u5de5\u751c\u5473\u5291\u5169\u985e\uff0c\u96a8\u8457\u751f\u916e\u8207\u4f4e\u78b3\u6c34\u5316\u5408\u7269\u98f2\u98df\u7684\u6d41\u884c\uff0c\u9019\u985e\u7cd6\u61c9\u7528\u7684\u6a5f\u6703\u4e5f\u96a8\u4e4b\u589e\u52a0\u3002\u4e00\u822c\u5e02\u9762\u4e0a\uff0c\u751c\u83ca\u6216\u7f85\u6f22\u679c\u8403\u53d6\u7269\u6703\u88ab\u6b78\u985e\u5728\u5929\u7136\u4ee3\u7cd6\uff1b\u800c\u963f\u65af\u5df4\u751c\u3001\u8517\u7cd6\u7d20\u3001\u7cd6\u7cbe\u2026\u7b49\u5247\u662f\u4eba\u5de5\u4ee3\u7cd6\u3002<\/p>\n\n\n<p>\u5c31\u76ee\u524d\u7684\u8a8d\u77e5\u662f\u4ee3\u7cd6\uff0c\u5728\u4eba\u9ad4\u5167\u4e0d\u6703\u50cf\u6b63\u5e38\u7684\u7cd6\u90a3\u6a23\u7684\u4ee3\u8b1d\uff0c\u56e0\u6b64\u5e7e\u4e4e\u6c92\u6709\u5361\u8def\u91cc\u800c\u88ab\u7528\u4f86\u53d6\u4ee3\u4e00\u822c\u7684\u7cd6\uff0c\u53ef\u80fd\u662f\u7528\u5728\u6e1b\u91cd\u8a34\u6c42\u7684\u7522\u54c1\uff0c\u6216\u662f\u8b93\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f7f\u7528\u3002\u8fd1\u5e74\u4f86\uff0c\u4e5f\u6709\u4e9b\u751f\u916e\u98f2\u98df\u7684\u98df\u8b5c\u4e5f\u6703\u7528\u4e0a\u9019\u985e\u7684\u7cd6\uff0c\u4ee5\u6b64\u589e\u52a0\u98f2\u98df\u7684\u8b8a\u5316\u6027\uff0c\u4e0d\u904e\u901a\u5e38\u4f7f\u7528\u7684\u662f\u5929\u7136\u4f86\u6e90\u7684\u985e\u578b\u3002<\/p>\n\n\n<p>\u672c\u7bc7\u7814\u7a76\u4ee5\u4eba\u5de5\u70ba\u4e3b\u8981\u63a2\u8a0e\u5c0d\u8c61\uff0c\u95dc\u65bc\u5929\u7136\u4f86\u6e90\u662f\u5426\u6703\u6709\u985e\u4f3c\u7684\u4f5c\u7528\u561b&#8230;\u7531\u65bc\u6211\u9084\u6c92\u6709\u53bb\u627e\u76f8\u95dc\u8cc7\u6599\u7684\u95dc\u4fc2\uff0c\u5728\u9019\u7bc7\u5c31\u5148\u8df3\u904e\u5566\u3002<\/p>\n\n\n<h2 id=\"%e4%ba%ba%e5%b7%a5%e7%94%9c%e5%91%b3%e5%8a%91%e8%88%87%e8%85%b8%e9%81%93%e5%91%b3%e8%a6%ba%e6%8e%a5%e5%8f%97%e5%99%a8\" class=\"wp-block-heading\">\u4eba\u5de5\u751c\u5473\u5291\u8207\u8178\u9053\u5473\u89ba\u63a5\u53d7\u5668<\/h2>\n\n\n<p>\u6211\u5011\u820c\u982d\u4e0a\u7684\u5473\u857e\uff0c\u6709\u80fd\u611f\u77e5\u751c\u7684<strong>\u5473\u89ba\u63a5\u53d7\u5668<\/strong>\uff0c\u7d93\u904e\u611f\u89ba\uff0c\u5927\u8166\u80fd\u77e5\u9053\u6709\u6c92\u6709\u5403\u5230\u7cd6\uff0c\u800c\u4ee3\u7cd6\u4e5f\u662f\u5229\u7528\u80fd\u88ab<a href=\"https:\/\/nutrinote.co\/%e4%bb%a3%e7%b3%96-%e7%a0%82%e7%b3%96-%e5%a4%a7%e8%85%a6%e5%8f%8d%e6%87%89%e5%b7%ae%e7%95%b0-%e7%8a%92%e8%b3%9e%e7%b3%bb%e7%b5%b1\/\" target=\"_blank\" aria-label=\"\u5473\u89ba\u63a5\u53d7\u5668 (opens in a new tab)\" rel=\"noreferrer noopener\" class=\"rank-math-link\">\u5473\u89ba\u63a5\u53d7\u5668<\/a>\u8b58\u5225\u7684\u5206\u5b50\uff0c\u8207\u4e00\u822c\u7cd6\u4e0d\u540c\u7684\u662f\uff0c\u5b83\u5011\u6c92\u8fa6\u6cd5\u88ab\u4eba\u7d66\u5229\u7528\u7522\u80fd\u3002<\/p>\n\n\n<p>\u672c\u4f86\u61c9\u8a72\u662f\u9019\u6a23\u7684\uff0c\u4f46\u4f60\u53ef\u80fd\u4e0d\u77e5\u9053\uff0c\u5728\u4eba\u985e\u7684\u5c0f\u8178\u88e1\u9762\u4e5f\u6709\u5473\u89ba\u63a5\u53d7\u5668\uff0c\u96d6\u7136\u4e0d\u80fd\u50b3\u905e\u300c\u751c\u5473\u300d\u7684\u611f\u89ba\u7d66\u5927\u8166\uff0c\u4f46\u5b83\u5011\u4f3c\u4e4e\u662f\u628a\u8a0a\u606f\u50b3\u5230\u5225\u7684\u5730\u65b9\u53bb\u4e86\uff0c\u800c\u90a3\u4e9b\u5730\u65b9\u53ef\u80fd\u548c\u7cd6\u7684\u4ee3\u8b1d\u9014\u5f91\u6709\u95dc\uff0c\u63db\u53e5\u8a71\u8aaa\uff0c\u5c31\u7b97\u6c92\u5403\u5230\u771f\u7684\u7cd6\uff0c\u4ee3\u7cd6\u4e5f\u53ef\u80fd\u6fc0\u8d77\u985e\u4f3c\u7684\u53cd\u61c9\u3002<\/p>\n\n\n<p>\u96d6\u7136\u76ee\u524d\u7684\u7814\u7a76\u9084\u6c92\u6709\u660e\u78ba\u7684\u7d50\u8ad6\uff0c\u4f46\u6211\u89ba\u5f97\u9019\u65b9\u9762\u7684\u7814\u7a76\u9084\u6eff\u6709\u9817\u6709\u610f\u601d\uff0c\u5e95\u4e0b\u5c31\u4f86\u5206\u4eab\u5169\u7bc7\u76f8\u95dc\u7684\u7814\u7a76\u5427\uff01<\/p>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h2 id=\"%e8%94%97%e7%b3%96%e7%b4%a0%e8%ae%93%e5%81%a5%e5%ba%b7%e4%ba%ba%e8%83%b0%e5%b3%b6%e7%b4%a0%e6%95%8f%e6%84%9f%e5%ba%a6%e4%b8%8b%e9%99%8d%e7%9a%84%e7%a0%94%e7%a9%b6\" class=\"wp-block-heading\">\u8517\u7cd6\u7d20\u8b93\u5065\u5eb7\u4eba\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\u4e0b\u964d\u7684\u7814\u7a76<\/h2>\n\n\n<p>\u4eba\u5de5\u4ee3\u7cd6\u8207\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\u7814\u7a76\u7684\u524d\u63d0\u8207\u80cc\u666f\uff1a<\/p>\n\n\n<ul><li>\u904e\u53bb\u66fe\u7d93\u6709\u7814\u7a76\uff0c\u505a\u53e3\u670d\u8461\u8404\u7cd6\u8010\u53d7\u8a66\u9a57\u4e4b\u524d\uff0c\u5206\u5225\u8b93\u53d7\u8a66\u8005\u651d\u53d6\u8517\u7cd6\u7d20\u6216\u662f\u6c34\uff0c\u7d50\u679c\u767c\u73fe\u8517\u7cd6\u7d20\u7d44\u6703\u6709\u8f03\u9ad8\u8461\u8404\u7cd6\u8207\u80f0\u5cf6\u7d20\u6fc3\u5ea6\u7684\u60c5\u5f62\uff0c\u800c\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\u53ca\u80f0\u5cf6\u7d20\u64f4\u6e05\u7387\u4e5f\u986f\u8457\u6e1b\u5c11\u3002<\/li><li>\u53e6\u5916\uff0c\u4e5f\u6709\u7814\u7a76\u767c\u73fe\u5728\u651d\u53d6\u7cd6\u7cbe\uff08Saccharin\uff097 \u5929\u5f8c\uff0c7 \u4f4d\u53d7\u8a66\u8005\u4e2d\u6709 4 \u4f4d\u8840\u4e2d\u8461\u8404\u7cd6\u986f\u8457\u589e\u52a0\uff0c\u6703\u6709\u9019\u6a23\u7684\u7d50\u679c\u53ef\u80fd\u548c\u8178\u9053\u5fae\u751f\u7269\u7684\u6539\u8b8a\u6709\u95dc\u4fc2\uff0c\u800c\u9019\u500b\u9650\u91cf\u5f9e\u79fb\u690d\u4eba\u985e\u7684\u7cde\u4fbf\u5230\u8001\u9f20\u7684\u8a66\u9a57\u5f97\u5230\u4e86\u9a57\u8b49\uff0c\u8001\u9f20\u63a5\u53d7\u79fb\u690d\u5f8c\uff0c\u8461\u8404\u7cd6\u8010\u53d7\u4e5f\u53d7\u5230\u4e86\u5f71\u97ff\u3002<\/li><li>\u4e5f\u6709\u7814\u7a76\u767c\u73fe\u7d66\u4e88\u4ee3\u7cd6\uff0c\u6703\u589e\u52a0\u5c0f\u8178\u7d30\u80de\u7684 SGLT-1\uff08sodium-glucose cotransporter 1\uff09\u548c GLUT-2\uff08glucose transporter 2 \uff09\u8868\u73fe\uff0c\u56e0\u800c\u5f37\u5316\u5c0f\u8178\u5c0d\u8461\u8404\u7cd6\u7684\u5438\u6536\u80fd\u529b\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u5982\u679c\u5403\u4e86\u4ee3\u7cd6\u8207\u7cd6\u7684\u6df7\u548c\u98df\u7269\uff0c\u96d6\u7136\u6703\u6e1b\u5c11\u771f\u7cd6\u7684\u7528\u91cf\uff0c\u4f46\u5c0f\u8178\u7684\u5438\u6536\u80fd\u529b\u537b\u6703\u5927\u5e45\u589e\u52a0\u3002<\/li><\/ul>\n\n\n<p>\u4e00\u7bc7\u767c\u8868\u5728\u300a\u7f8e\u570b\u81e8\u5e8a\u71df\u990a\u5b78\u671f\u520a\u300b\u7684\u4eba\u9ad4\u8a66\u9a57\uff0c\u627e\u4f86\u4e00\u7fa4 18\u201355 \u6b72\u5e73\u5e38\u6c92\u4ec0\u9ebc\u5728\u5403\u4eba\u5de5\u4ee3\u7cd6\u7684\u5065\u5eb7\u7537\u5973\uff0c\u4ed6\u5011\u6c92\u6709\u7cd6\u5c3f\u75c5\u6216\u524d\u671f\u7cd6\u5c3f\u75c5\uff0c\u4e5f\u6c92\u6709\u670d\u7528\u4efb\u4f55\u53ef\u80fd\u5e72\u64fe\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\u7684\u85e5\u7269\u3002\u7814\u7a76\u96a8\u6a5f\u628a\u53c3\u8207\u8005\u5206\u6210\u8517\u7cd6\u7d20\u7d44\u8207\u63a7\u5236\u7d44\uff08\u6c92\u5403\uff09\uff0c\u9023\u7e8c\u9032\u884c 14 \u5929\u3002\u671f\u9593\uff0c\u7d66\u4e88\u4eba\u4ee3\u7cd6\u524d\u5f8c\u7684\u4e09\u5c0f\u6642\uff0c\u6e2c\u91cf\u80f0\u5cf6\u7d20\u654f\u611f\u6027\u3001\u6025\u6027\u80f0\u5cf6\u7d20\u5c0d\u8461\u8404\u7cd6\u53cd\u61c9\u8461\u8404\u7cd6\u6548\u529b\u7b49\u9805\u76ee\u3002<\/p>\n\n\n<p>\u53e6\u5916\u4e00\u7bc7\u7814\u7a76\u767c\u8868\u5728\u300a\u71df\u990a\u5b78\u671f\u520a\u300b\u4e0a\uff0c\u53d7\u8a66\u8005\u5011\u90fd\u662f\u8eab\u9ad4\u5065\u5eb7\uff0c\u4e14\u8461\u8404\u7cd6\u8010\u91cf\u8a66\u9a57\u6b63\u5e38\u7684\u6210\u5e74\u4eba\u3002\u96a8\u6a5f\u5206\u914d\u5b83\u5011\u5403\u542b\u6709 200 \u6beb\u514b\u7684\u8517\u7cd6\u7d20\u6216\u5b89\u6170\u5291\u81a0\u56ca\uff0c\u9023\u7e8c\u56db\u5468\uff0c\u7d50\u675f\u4e4b\u5f8c\u518d\u4ea4\u63db\u7d44\u5225\u9032\u884c\u8a66\u9a57\u3002<\/p>\n\n\n<p>\u8840\u7cd6\u3001\u80f0\u5cf6\u7d20\u3001\u6d3b\u5316 GLP-1 \u6fc3\u5ea6\u6703\u5728\u5403\u4e0b 75 \u516c\u514b\u8461\u8404\u7cd6\u5f8c\u91cf\u6e2c\uff0c\u9694\u5929\u6703\u518d\u91cf\u6e2c IVGTT\uff08intravenous glucose tolerance test\uff09\u8a55\u4f30\u6025\u6027\u80f0\u5cf6\u7d20\u53cd\u61c9\uff08AIR\uff09\u3002\u7d50\u679c\u767c\u73fe\u8517\u7cd6\u7d20\u7d44\u5728\u5403\u4e0b\u8517\u7cd6\u7d20\u4e4b\u5f8c AIR \u986f\u8457\u4e0b\u964d\uff0c\u4e14\u6d3b\u5316\u7684 GLP-1 \u7684\u66f2\u7dda\u4e0b\u9762\u7a4d\u4e5f\u662f\u8517\u7cd6\u7d20\u7d44\u6bd4\u8f03\u9ad8\uff0c\u4e5f\u5c31\u662f\u8aaa\u6301\u7e8c\u63a5\u89f8\u8517\u7cd6\u7d20\u6703\u6e1b\u5c11 AIR\u3001\u964d\u4f4e\u80f0\u5cf6\u7d20\u654f\u611f\u5ea6\uff0c\u4e26\u4e14\u4fc3\u9032 GLP-1 \u7684\u91cb\u653e\u3002\u81f3\u65bc\u5728\u81e8\u5e8a\u4e0a\u6703\u5e36\u4f86\u4ec0\u9ebc\u6a23\u7684\u5f71\u97ff\uff0c\u5c31\u5f97\u8981\u6709\u8f03\u9577\u671f\u7684\u8ffd\u8e64\u7814\u7a76\u624d\u6709\u8fa6\u6cd5\u77e5\u9053\u4e86\u3002<\/p>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<h2 id=\"glp-1-%e6%98%af%ef%bc%9f\" class=\"wp-block-heading\">GLP-1 \u662f\uff1f<\/h2>\n\n\n<p>\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd-1\uff08GLP-1\uff09\u662f\u4e00\u7a2e\u4e3b\u8981\u7531\u8178\u9053L\u7d30\u80de\u6240\u7522\u751f\u7684\u6fc0\u7d20\uff0c\u7531 30 \u500b\u80fa\u57fa\u9178\u7d44\u6210\uff0c\u5c6c\u65bc\u4e00\u7a2e\u8178\u4fc3\u80f0\u5cf6\u7d20\uff08incretin\uff09\u3002\u751f\u7406\u5982\u4e0b\u4f5c\u7528\uff1a<\/p>\n\n\n<ul><li>\u4fc3\u9032\u80f0\u81df \u03b2-\u7d30\u80de\u7684\u80f0\u5cf6\u7d20\u5206\u6ccc<\/li><li>\u6291\u5236\u80f0\u81df \u03b1-\u7d30\u80de\u7684\u80f0\u9ad8\u8840\u7cd6\u7d20\u5206\u6ccc<\/li><li>\u5ef6\u7de9\u80c3\u6392\u7a7a<\/li><li>\u85c9\u7531\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u6291\u5236\u98df\u617e<\/li><\/ul>\n\n\n\n\n<ol><li>Gerspach, A. C., Steinert, R. E., Sch\u00f6nenberger, L., Graber-Maier, A., &amp; Beglinger, C. (2011). The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans. American Journal of Physiology-Endocrinology and Metabolism, 301(2), E317-E325.<\/li><li>Alonso Romo-Romo, Carlos A Aguilar-Salinas, Griselda X Brito-C\u00f3rdova, Rita A G\u00f3mez-D\u00edaz, Paloma Almeda-Valdes; Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial, The American Journal of Clinical Nutrition, Volume 108, Issue 3, 1 September 2018, Pages 485\u2013491, <a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1093\/ajcn\/nqy152\" target=\"_blank\">https:\/\/doi.org\/10.1093\/ajcn\/nqy152<\/a><\/li><li>Lertrit, A., Srimachai, S., Saetung, S., Chanprasertyothin, S., Chailurkit, L. O., Areevut, C.,&nbsp;\u2026 &amp; Sriphrapradang, C. (2018). Effects of Sucralose on Insulin and GLP-1 Secretion in Healthy Subjects: A Randomized Double-Blind, Placebo Controlled Trial. 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