{"id":120,"date":"2017-09-22T13:57:11","date_gmt":"2017-09-22T05:57:11","guid":{"rendered":"http:\/\/tre.tech.blog\/2017\/09\/22\/%e7%bd%b9%e6%82%a3%e7%b3%96%e5%b0%bf%e7%97%85%e8%bc%83%e5%ae%b9%e6%98%93%e5%86%8d%e5%be%97%e9%80%80%e5%8c%96%e6%80%a7%e9%97%9c%e7%af%80%e7%82%8e%ef%bc%8c%e7%b3%96%e5%8c%96%e7%b5%82%e7%94%a2%e7%89%a9\/"},"modified":"2017-09-22T13:57:11","modified_gmt":"2017-09-22T05:57:11","slug":"osteoarthritis-dm-ages","status":"publish","type":"post","link":"https:\/\/nutrinote.co\/osteoarthritis-dm-ages\/","title":{"rendered":"\u7f79\u60a3\u7cd6\u5c3f\u75c5\u8f03\u5bb9\u6613\u518d\u5f97\u9000\u5316\u6027\u95dc\u7bc0\u708e\uff0c\u7cd6\u5316\u7d42\u7522\u7269\u53ef\u80fd\u662f\u539f\u56e0\u4e4b\u4e00\uff1f"},"content":{"rendered":"\n

\u5c31\u8a8d\u77e5\u4e0a\u9000\u5316\u6027\u95dc\u7bc0\u708e<\/strong>\uff08Osteoarthritis, \u7c21\u7a31 OA\uff09\u597d\u50cf\u662f\u4e00\u7a2e\u5e74\u7d00\u5230\u4e86\u5c31\u5f88\u96e3\u907f\u514d\u7684\u4e00\u7a2e\u75be\u75c5\uff0c\u901a\u5e38\u9810\u9632\u7684\u91cd\u9ede\u6703\u5728\u65bc\u597d\u597d\u4fdd\u8b77\u95dc\u7bc0\u3001\u935b\u934a\u808c\u8089\u5e6b\u52a9\u652f\u6490\uff0c\u800c\u5728\u71df\u990a\u88dc\u5145\u6216\u662f\u85e5\u54c1\u4e0a\uff0c\u975e\u8b8a\u6027\u4e8c\u578b\u81a0\u539f\u86cb\u767d<\/strong>\u3001\u8461\u8404\u7cd6\u80fa<\/strong>\u6216\u662f\u7dad\u9aa8\u529b<\/strong>\u2026\u7b49\u5c31\u662f\u5f88\u5e38\u51fa\u73fe\u7684\u9078\u64c7\u3002<\/p>\n\n\n

\u7136\u800c\u5f9e\u6d41\u884c\u75c5\u5b78\u7684\u89c0\u5bdf\uff0c\u7f79\u60a3\u7cd6\u5c3f\u75c5\u7684\u4eba\uff0c\u6709\u8f03\u9ad8\u7f79\u60a3 OA \u7684\u98a8\u96aa\uff0c\u4f46\u70ba\u4ec0\u9ebc\u6703\u6709\u9019\u6a23\u7684\u7d50\u679c\u5462\uff1f\u53ef\u80fd\u7684\u539f\u56e0\u5f88\u591a\uff0c\u5728\u6b64\u8b93\u6211\u5011\u5f9e\u7cd6\u5316\u7d42\u7522\u7269<\/a>\uff08advanced glycation end-products, \u7c21\u7a31 AGEs\uff09\u7684\u89d2\u5ea6\u4f86\u7814\u7a76\u7814\u7a76\u3002<\/p>\n\n\n

PS\uff1a\u672c\u6587\u7684\u7cd6\u5c3f\u75c5\u90fd\u662f\u6307\u7b2c\u4e8c\u578b\u7cd6\u5c3f\u75c5\u3002<\/strong><\/p>\n\n\n

\u4ec0\u9ebc\u662f\u7cd6\u5316\u7d42\u7522\u7269\uff08AGEs\uff09<\/h3>\n\n\n\n

\u7c21\u55ae\u7684\u8aaa\u5c31\u662f\u9084\u539f\u7cd6\uff08\u5305\u542b\u8461\u8404\u7cd6\u3001\u679c\u7cd6\u2026\u7b49\uff09\u548c\u86cb\u767d\u8cea\u6216\u8102\u8cea\u7d93\u904e\u4e00\u9023\u4e32\u53cd\u61c9\u5f8c\u7522\u751f\u7684\u7269\u8cea<\/strong>\u3002\u51fa\u73fe\u8f09\u4eba\u9ad4\u5167\u7684 AGEs \u6709\u5169\u7a2e\u4f86\u6e90\uff0c\u4e00\u7a2e\u4f86\u81ea\u98df\u7269\uff1b\u53e6\u4e00\u7a2e\u5247\u5728\u9ad4\u5167\u751f\u6210\u3002<\/p>\n\n\n

\u98df\u7269\u8207\u9ad4\u5167\u751f\u6210\u7684 AGEs \u904e\u7a0b\u4e26\u4e0d\u76f8\u540c\uff0c\u65b0\u9bae\u6216\u672a\u904e\u5ea6\u52a0\u5de5\u7684\u98df\u7269 AGEs \u542b\u91cf\u8f03\u5c11\uff0c\u4e00\u65e6\u7d93\u904e\u9ad8\u6eab\u3001\u9ad8\u58d3\u8207\u4f4e\u6c34\u4efd\u70f9\u8abf\u2026\u7b49\u8655\u7406\uff0c\u98df\u7269\u7684 AGEs \u5c31\u6703\u6709\u4e0d\u540c\u7a0b\u5ea6\u7684\u589e\u52a0\u3002\u81f3\u65bc\u4eba\u9ad4\u5167\u7684 AGEs\uff0c\u53ea\u8981\u9084\u539f\u7cd6\u78b0\u5230\u86cb\u767d\u8cea\u8207\u8102\u8cea\u5c31\u6709\u53ef\u80fd\u767c\u751f\u3002<\/p>\n\n\n

\u8207\u7cd6\u53cd\u61c9\u8b8a\u6210 AGEs \u7684\u86cb\u767d\u8cea\u6216\u662f\u8102\u8cea\u6703\u5931\u53bb\u539f\u6709\u7684\u529f\u80fd\uff0c\u4e26\u6703\u4fc3\u4f7f\u81ea\u7531\u57fa\u7684\u751f\u6210\uff0c\u4f7f\u6c27\u5316\u58d3\u529b\u589e\u52a0\u2026 \u6301\u7e8c\u767c\u5c55\u4e0b\u53bb\u5c31\u662f\u8a31\u591a\u4f60\u5e38\u807d\u5230\u7684\u6162\u6027\u75be\u75c5\u3002<\/p>\n\n\n

\"\u9000\u5316\u6027\u95dc\u7bc0\u708e-AGEs\"
\u70e4\u96de\u542b\u6709\u5927\u91cf\u7684 AGEs\uff0c\u53ef\u4ee5\u7684\u8a71\u907f\u514d\u77ed\u6642\u9593\u5167\u5e38\u5e38\u5403\u3002Photo by Gabriel Garcia Marengo<\/a> on Unsplash<\/a><\/figcaption><\/figure>\n\n\n

<\/p>\n\n\n

\u7cd6\u5c3f\u75c5\u4fc3\u4f7f\u9ad4\u5167 AGEs \u589e\u52a0<\/h2>\n\n\n

\u7f79\u60a3 DM \u7684\u4eba\u5982\u679c\u6c92\u6709\u597d\u597d\u63a7\u5236\u98f2\u98df\u8207\u990a\u6210\u904b\u52d5\u7fd2\u6163\u7684\u8a71\uff0c\u8840\u7cd6\u5c31\u5f88\u5bb9\u6613\u63a7\u5236\u5f97\u4e0d\u597d\uff0c\u5c31\u5bb9\u6613\u6709\u9ad8\u8840\u7cd6\u7684\u60c5\u5f62\u3002\u8840\u7cd6\u6fc3\u5ea6\u9ad8\u7684\u8a71\uff0c\u9019\u4e9b\u7cd6\u5728\u5faa\u74b0\u671f\u9593\u5c31\u6bd4\u8f03\u5bb9\u6613\u649e\u5230\u86cb\u767d\u8cea\u6216\u662f\u8102\u8cea\u800c\u4e0d\u5c0f\u5fc3\u53cd\u61c9\u6210 AGEs\uff0c\u6b64\u5916\uff0c\u5927\u91cf\u7684\u8461\u8404\u7cd6\u9032\u5165\u7d30\u80de\uff0c\u4ee3\u8b1d\u904e\u7a0b\u671f\u9593\u7684\u4e2d\u9593\u7522\u7269\u4e5f\u53ef\u80fd\u6703\u4e0d\u5c0f\u5fc3\u767c\u5c55\u6210 AGEs\u3002<\/p>\n\n\n

\u8840\u4e2d\u7684\u5404\u7a2e\u86cb\u767d\u8cea\u6216\u662f\u8840\u7ba1\u7684\u81a0\u539f\u86cb\u767d\u5c31\u662f\u5faa\u74b0\u4e2d\u53ef\u80fd\u8b8a\u6210 AGEs \u7684\u53d7\u5bb3\u8005\uff1b\u800c\u5728\u7d30\u80de\u5167\uff0c\u5c31\u53ef\u80fd\u5f71\u97ff\u7d30\u80de\u7684\u6b63\u5e38\u529f\u80fd\u3002\u9019\u6a23\u770b\u4f86\uff0cAGEs \u597d\u50cf\u6709\u5f88\u5927\u7684\u5371\u5bb3\u5474\uff01\u5176\u5be6\u9762\u5c0d\u9019\u4e9b\u72c0\u6cc1\uff0c\u4eba\u9ad4\u65e9\u5c31\u767c\u5c55\u51fa\u597d\u5e7e\u7a2e\u9632\u79a6\u6a5f\u5236\u61c9\u5c0d\uff0c\u4e0d\u904e\u9019\u9632\u79a6\u4e26\u4e0d\u662f\u4e00\u76f4\u90fd\u80fd\u6709\u6548\u767c\u63ee\uff0c\u4e00\u65e6\u8d85\u904e\u8ca0\u8377\uff0c\u8eab\u9ad4\u5c31\u6703\u51fa\u73fe\u4e00\u4e9b\u7570\u6a23\u3002<\/p>\n\n\n

AGEs \u8207\u9000\u5316\u6027\u95dc\u7bc0\u708e<\/h2>\n\n\n

2016 \u5e74\uff0c\u5728\u300aOsteoarthritis and cartilage\u300b\u671f\u520a\u4e0a\u6709\u4e00\u7bc7\u52d5\u7269\u8a66\u9a57\uff0c\u8a66\u9a57\u4e86AGEs \u5c0d\u95dc\u7bc0\u708e\u767c\u5c55\u7684\u5f71\u97ff\u3002\u7814\u7a76\u6709\u5169\u500b\u8a66\u9a57\uff0c\u5176\u4e00\u662f\u4ee5\u95dc\u7bc0\u5167\u6ce8\u5c04\u4e0d\u540c\u6fc3\u5ea6\u7684\u6838\u7cd6\uff08D-ribose\uff09\u6216\u78f7\u9178\u9e7d\u7de9\u885d\u751f\u7406\u9e7d\u6c34\u5230\u5154\u5b50\u53f3\u819d\u84cb\uff0c\u6ce8\u5c04\u7cd6\u80fd\u8a98\u4f7f AGEs \u751f\u6210\uff0c\u6ce8\u5c04\u751f\u7406\u6642\u9e7d\u6c34\u7684\u5154\u5b50\u662f\u5c0d\u7167\u7d44\u3002\u63a5\u8457\u4ee5\u5927\u91cf\u7684\u904b\u52d5\u8b93\u5154\u5b50\u7f79\u60a3\u9000\u5316\u6027\u95dc\u7bc0\u708e\uff0c\u7d50\u679c\u767c\u73fe AGEs \u591a\u7684\u5154\u5b50\u95dc\u7bc0\u640d\u50b7\u6bd4\u8f03\u56b4\u91cd\u3002<\/p>\n\n\n

\u7b2c\u4e8c\u6b21\u8a66\u9a57\uff0c\u6240\u6709\u7684\u5154\u5b50\u53f3\u819d\u95dc\u7bc0\u90fd\u88ab\u6ce8\u5c04\u7cd6\u4ee5\u8a98\u767c AGEs \u751f\u6210\uff0c\u4e26\u8b93\u5b83\u5011\u53e3\u670d\u7cd6\u5c3f\u75c5\u85e5\u7269\uff08pioglitazone\uff09\u6216\u5b89\u6170\u5291\uff0c\u7d50\u679c\u767c\u73fe\u53e3\u670d\u7cd6\u5c3f\u75c5\u85e5\u7269\u80fd\u6e1b\u8f15\u9000\u5316\u6027\u95dc\u7bc0\u708e\u7684\u56b4\u91cd\u5ea6\u3002<\/p>\n\n\n

\u4e5f\u5c31\u662f\u8aaa AGEs \u53ef\u80fd\u6703\u52a0\u901f\u95dc\u7bc0\u8edf\u9aa8\u7684\u5206\u89e3\uff0c\u8b93 OA \u8b8a\u5f97\u66f4\u56b4\u91cd\u3002\u63a5\u4e0b\u4f86\u7684\u7814\u7a76\u5247\u66f4\u4e00\u6b65\u53bb\u89c0\u5bdf\u4eba\u985e\u7684\u60c5\u5f62\u3002<\/p>\n\n\n

\"\"
Photo by Sylvanus Urban<\/a> on Unsplash<\/a><\/figcaption><\/figure>\n\n\n

AGEs\u3001OA \uff06 DM \u7684\u95dc\u4fc2<\/h2>\n\n\n

\u9019\u662f\u4e00\u7bc7\u5728 2017 \u5e74 9 \u6708 12 \u65e5\u767c\u8868\u5728\u3008PLOS | ONE\u3009\u671f\u520a\u4e0a\u7684\u7814\u7a76\u3002\u7e3d\u5171\u6709 84 \u4f4d\u8981\u9032\u884c\u95dc\u7bc0\u7f6e\u63db\u624b\u8853\u7684 OA \u60a3\u8005\u53c3\u8207\uff0c\u5176\u4e2d\u6709 46 \u4f4d\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c\u53e6\u5916 38 \u4f4d\u5247\u7121\u3002\u7814\u7a76\u6703\u8490\u96c6\u60a3\u8005\u7684\u9694\u591c\u81f3\u5c11\u7a7a\u8179 8 \u5c0f\u6642\u7684\u8840\u6db2\u4ee5\u53ca\u95dc\u7bc0\u6ed1\u6db2\u7684\u6a23\u672c\u3002\uff08\u95dc\u7bc0\u6ed1\u6db2\u7684\u6a23\u672c\u662f\u5728\u75c5\u60a3\u9032\u884c\u624b\u8853\u6642\u53d6\u5f97\u3002\uff09<\/p>\n\n\n

\u53d6\u5f97\u6a23\u672c\u5f8c\uff0c\u4ee5\u5100\u5668\u53bb\u5206\u6790\u8840\u6db2\u8207\u95dc\u7bc0\u6ed1\u6db2\u88e1\u7684 AGEs \u548c\u78f7\u8102\u91af\u81bd\u9e7c\uff08phosphatidylcholine\uff0c\u5099\u8a3b1\uff09\u3002\u5206\u6790\u7684 AGEs \u5305\u542b\u4ee5\u4e0b\u56db\u7a2e\uff1a<\/p>\n\n\n

  1. MG = methyglyoxal<\/li>
  2. MG-H1 = free methylglyoxal-derived hydroimidazolone<\/li>
  3. CML = protein bound N-(Carboxymethyl)lysine<\/li>
  4. CEL = N-(Carboxyethyl)lysine<\/li><\/ol>\n\n\n

    \u7531\u65bc\u8981\u628a\u4e0a\u9762\u56db\u7a2e\u8aaa\u6e05\u695a\u5f97\u8981\u4e00\u4e9b\u7bc7\u5e45\uff0c\u672a\u4f86\u518d\u627e\u6a5f\u6703\u89e3\u8aaa\uff0c\u73fe\u5728\u53ea\u8981\u5927\u6982\u77e5\u9053\u9ad4\u5167\u8840\u7cd6\u6fc3\u5ea6\u9ad8\u7684\u8a71\uff0c\u9019\u4e9b AGEs \u5c31\u53ef\u80fd\u6703\u6bd4\u8f03\u591a\u3002\uff08\u771f\u7684\u5f88\u60f3\u77e5\u9053\u7684\u4eba\u8acb\u53c3\u8003\u6587\u737b 3\uff09<\/p>\n\n\n

    \u7d93\u904e\u7d71\u8a08\u5206\u6790\u5f8c\uff0c\u60a3\u8005\u5011\u4e0d\u7ba1\u6709\u6c92\u6709\u7f79\u60a3 DM\uff0c\u8840\u6db2\u4e2d\u56db\u7a2e AGEs \u4e26\u6c92\u6709\u51fa\u73fe\u986f\u8457\u7684\u5dee\u7570\u3002\u4f46\u5728\u95dc\u7bc0\u6ed1\u6db2\u7684\u7d50\u679c\u5c31\u6709\u610f\u601d\u4e86\uff0c\u60a3\u6709\u7cd6\u5c3f\u75c5\u7684 OA \u60a3\u8005\uff0cMG \u8207 MG-H1 \u7684\u6fc3\u5ea6\u986f\u8457\u8f03\u9ad8\uff08\u78f7\u8102\u91af\u81bd\u4e5f\u662f\uff09\u3002<\/p>\n\n\n

    \u7814\u7a76\u8005\u5011\u8a8d\u70ba\u6b64\u7814\u7a76\u7684\u7d50\u679c\u6216\u8a31\u80fd\u5e6b\u52a9\u89e3\u91cb\u70ba\u4ec0\u9ebc\u7cd6\u5c3f\u75c5\uff08DM\uff09\u60a3\u8005\u6709\u8f03\u9ad8\u7684\u98a8\u96aa\u7f79\u60a3\u9000\u5316\u6027\u95dc\u7bc0\u708e\uff08OA\uff09\uff0c\u540c\u6642\u9019\u4e5f\u80fd\u66f4\u5f37\u8abf\u8840\u7cd6\u63a7\u5236\u5728\u7cd6\u5c3f\u75c5\u7ba1\u7406\u7684\u91cd\u8981\u6027\u3002<\/p>\n\n\n\n\n

    <\/div>\n\n\n\n\n
    1. Li, Y., Zhang, Y., Chen, C., Zhang, H., Ma, C., & Xia, Y. (2016). Establishment of a rabbit model to study the influence of advanced glycation end products accumulation on osteoarthritis and the protective effect of pioglitazone.<\/li>
    2. Osteoarthritis and cartilage, 24(2), 307\u2013314.Zhang W, Randell EW, Sun G, Likhodii S, Liu M, Furey A, et al. (2017) Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes. PLoS ONE 12(9): e0184105.<\/li>
    3. Takeuchi, M. (2016). Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker for the onset\/progression of lifestyle-related diseases. Diagnostics, 6(2), 23.<\/a><\/li><\/ol>\n\n\n

      <\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

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